Taking A Closer Look at Vitamin D

The role of vitamin D in the prevention and treatment of many kinds of cancer continues to intrigue cancer scientists. Researchers at Roswell Park Cancer Institute are exploring the use of vitamin D in treating a subtype of lung cancer that mainly occurs in women and non-smokers.  

The subtype is referred to as EGRF-mutant lung cancer, after the mutated protein that is often linked to its development—Epidermal Growth Factor Receptor. Drugs that block the action of EGFR are available and have been shown to initially be effective in patients with EGFR-mutant lung cancer.  Unfortunately, patients with EGFR- mutant lung cancer who receive these drugs can sometimes show disease progression after approximately one year of treatment because the tumor cells become resistant to the drug.

“Effective and safe strategies to achieve longer lasting disease control are urgently needed in order to improve the long-term outcome for these individuals,” said Dr. Hershberger. “Our hope is that positive results from our studies can be rapidly developed into lung cancer clinical trials."

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